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Cohort profile update: the Korean Cancer Prevention Study-II Biobank
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Heejin Kimm, Keum Ji Jung, Wes Spiller, Yeun Soo Yang, So Young Kim, Min Young Park, Sun Mi Lee, Sun Ha Jee
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Epidemiol Health. 2025;e2025040. Published online July 29, 2025
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DOI: https://doi.org/10.4178/epih.e2025040
[Accepted]
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 Abstract
Summary
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Abstract
Chronic diseases such as cancer and cardiovascular disease have a substantial impact on mortality and global disease burden. The Korean Cancer Prevention Study-II (KCPS-II) biobank was established to investigate these chronic diseases, with a particular focus on metabolic risk factors. Recently, genetic information reflecting diverse ancestries has been incorporated to support a precision medicine approach. These data can be leveraged to identify variation in causal effects among different ancestral groups, thereby informing the development of more effective, ancestry-specific treatments. From 2004 to 2013, baseline data were collected from 156,701 individuals aged 20–85 years, recruited from 18 health promotion centres across South Korea. Outcome data are routinely obtained from Statistics Korea (mortality data), the National Cancer Centre (cancer registry data), and the National Health Insurance Service (morbidity data). Additionally, new participants have been enrolled since 2022 as part of an ongoing expansion. This population-based cohort, enriched with genetic data, provides a robust foundation for research aimed at elucidating causal relationships in chronic disease.
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Summary
Korean summary
· 한국 암 예방 연구 II 바이오 뱅크에는 한국 전역의 18개 건강 검진 센터에서 모집한 20~85세의 156,701명의 참여자가 포함되어 있다.
· 모집 시 기준 측정에는 사회 경제적, 병력, 행동적, 생리적 및 혈액 샘플 데이터가 포함되어 있으며, 이들의 유전 분석이 완료되었다.
· 한국 암 예방 연구 II는 현재 참여자를 모집하고 있는 진행 중인 코호트이며, 사망률 외에도 심혈관 및 암 이환율을 포함한 2차 자료 연계를 통해 후속 데이터를 사용할 수 있다.
· 본 코호트를 통해 한국인의 역학 자료와 유전 자료를 이용하여 질병에 대한 매커니즘을 확인하고 질병 예방 및 극복에 대한 과학적 근거를 창출할 것으로 기대한다.
Key Message
· The Korean Cancer Prevention Study II (KCPS-II) Biobank comprises 156,701 adults aged 20–85 years, recruited from 18 health examination centers nationwide.
· Baseline data include socioeconomic, medical history, behavioral, physiological, and blood sample information, with completed genetic analyses.
· KCPS-II is an ongoing cohort with follow-up through linkage to secondary data on mortality, cardiovascular events, and cancer incidence.
· This resource enables the integration of epidemiological and genetic data to investigate disease mechanisms and provide scientific evidence for prevention and control in the Korean population.
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